عنوان مقاله [English]
Introduction: In this research, nanoparticles were synthesized by two methods of hemolipation and precipitation-reduction under optimal conditions. Using X-Ray Diffraction and Fourier Infrared Spectroscopy (FTIR) tests, the optimal conditions for nanoparticle synthesis were determined by sediment-reduction method. Finally, by analyzing the images taken by electron microscopy from two samples, the average size of magnetite nanoparticles synthesized by co-precipitation method was measured at 39nm and by sediment-reduction method at 4/5nm. By plotting the particle size distribution, in the co-precipitation method, the particle size distribution of nanoparticles was relatively wide and in the sediment-reduction method, the relatively narrow particle size distribution was obtained. Finally, by comparing the average size, distribution, particle size and morphology of nanoparticles synthesized by the two methods mentioned, magnetite nanoparticles synthesized by sediment-reduction method are proposed for drug delivery applications.
Material and methods: This is a research study involving experiments and reviewing library studies on controlled drug delivery systems. After conducting library studies and obtaining sufficient information, laboratory tests of this study were performed.
Results: With the creation of particle systems, new properties were introduced into drugs that did not exist before. The use of nanoparticles has led to its optimization and has created features such as therapeutic target, improved cell permeability, longer life, etc. that were not previously available in conventional drugs. Nanoparticles synthesized by the deposition-reduction method, which are more synthetic than the co-precipitation method, have a higher purity, a much smaller particle size, and a narrower particle size distribution. Due to the fact that magnetite nanoparticles in sizes below 15 nm show the properties of paramagnetic cloud and also nanoparticles suitable for pharmaceutical applications should have a uniform distribution of particle size, nanoparticles synthesized by sediment-reduction method are recommended for drug delivery applications.
Conclusion: Due to the fact that magnetite nanoparticles in sizes below 15 nm show superparamagnetic properties and also nanoparticles suitable for pharmaceutical applications should have a uniform distribution of particle size, nanoparticles synthesized by sedimentary-reduction method for drug delivery applications are recommended.