نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه فیزیولوژی جانوری، دانشکده علوم پایه، دانشگاه آزاد اسلامی، قم، ایران
2 گروه فیزیولوژی، دانشکده پزشکی، دانشگاه آزاد اسلامی، قم، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Aim and Background: Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease and the most common cause of disability . it is a progressive disease that is associated with the destruction of nerve cells. Caloric restriction is the only preventive action that has a life long-lasting effect on laboratory models. It has been shown in a large scale of laboratory animals that caloric restriction increases life expectancy, decreases the incidence of several age-related diseases, and preserves youth activities. Therefore, the aim of this study was to investigate the effect of caloric restriction diet on reserpine-induced catalepsy in male rats model of Parkinson's disease. Material and Methods: In this study, 30 Wistar rats were divided in 5 groups (control, Parkinson's disease,caloric restriction, Parkinson's disease + caloric restriction, caloric restriction+ Parkinson's disease(2) ).Animals in caloric restriction groups were under the caloric restriction of 30 percent. Parkinson's disease was induced by administration of Reserpine (1 mg/kg, i.p). The bar- test was used to measure cataleptic symptoms.
Results: catalepsy was significantly lower in of caloric restriction + Parkinson's disease and caloric restriction+ Parkinson's disease (2) groups than in Parkinson's disease group. (P <0/05). Conclusion: caloric restriction of 30 percent can improve reserpine-induced catalepsy in male rats model of Parkinson's disease. Also, caloric restriction before inducing Parkinson's disease reduces the severity of complications after getting sick, including catalepsy.
کلیدواژهها [English]
)